ENTEROVIRUS TYPE 70-NEUTRALIZING IgM IN ANIMAL SERA

Enterovirus type 70 virion and intracellular proteins.

The proteins of purified enterovirus type 70 grown in rhabdomyosarcoma cells and the intracellular proteins at 4 to 5 h after infection have been examined by polyacrylamide gel electrophoresis. Virions contained four proteins: P-1 (35,000, daltons) P-2 (28,000, daltons) P-3 (27,000, daltons) and P-4 (9,000 daltons). Further, addition of ZnCl2 to infected cultures inhibited virus plaque developm...

Neutralizing antibodies to enterovirus 71 in Belém, Brazil.

Non-polio enteroviruses (Coxsackievirus A, Coxsackievirus B, Echovirus and EV 68-72) which belong to the enterovirus (EV) genus, Picornaviridae family, may be responsible for acute flaccid paralysis, aseptic meningitis, myocarditis, hepatitis, pleurodinia, neonatal sepsis, hand, foot and mouth disease (HFMD) even though 50-80% of infections are asymptomatic. EV 71 has been responsible for outbr...

Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors.

Attempts to elicit broadly neutralizing antibody responses by human immunodeficiency virus type 1 (HIV-1) vaccine antigens have been met with limited success. To better understand the requirements for cross-neutralization of HIV-1, we have characterized the neutralizing antibody specificities present in the sera of three asymptomatic individuals exhibiting broad neutralization. Two individuals ...

An enterovirus type 70 epidemic of acute conjunctivitis in peninsular Malaysia, 1980.

Outbreaks of acute viral conjunctivitis due to enteroviruses have been recorded in Malaysia since 1969 when enterovirus type 70 was incriminated for the first time as a cause of acute haemorrhagic conjunctivitis (AHC) throughout the world in 1969-71. The pandemic was reported in Africa, Asia (including Malaysia) and England (Mirkovic et al., 1973). The outbreak in Malaysia then was localised to...

Animal Sera for Transfusion Purposes